Pernot, Mathieu (2004) Nouvelles techniques de thérapie ultrasonore et de monitoring. PhD thesis Physique, Laboratoire Ondes et Acoustique, ESPCI.
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Alternative Locations: http://www.loa.espci.fr/~pernot/fr/dir/TheseMathieuPernot.pdf
Abstract
High Intensity Focused Ultrasound (HIFU) is a promising technique for the treatment of localized cancers. The ability to focus ultrasound precisely on a predetermined volume allows the possibility of selective tissue destruction at this position without damage to surrounding tissues. However, many difficulties remain in the treatment of deep-seated tumors. In this thesis, new therapeutic and monitoring techniques are proposed to address these problems, by using phased arrays of ultrasound transducers. Two monitoring techniques based on the detection of the displacements of the ultrasonic speckle are developed, and allowed us to image the changes in the temperature and the shear modulus during HIFU therapy. In-vitro ultrasound-guided experiments are performed. Secondly, the problem of organs motion during the treatment is addressed. A method for real-time tracking the 3D motion of tissues is combined with a 2D High Intensity Focused Ultrasound multi-channel system in order to correct the respiratory motion during HIFU therapies. In the last section of this thesis, a high power ultrasonic system is developed for transcranial HIFU brain therapy. The skulls aberrations are corrected using a time reversal mirror thanks to an implanted hydrophone. In-vivo experiments are conducted on 22 sheep with minimally invasive surgery. Finally, a non-invasive protocol based on CT scans of the entire skull is developed and allows the prediction of the skulls aberrations and the skull overheating.
| Item Type: | PhD Thesis (PhD) |
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| Thesis Supervisor: | Fink, Mathias |
| Date: | October 2004 |
| Board of examiners: | Boccara, Claude and Cathignol, Dominique and Laugier, Pascal and Moonen, Chrit and Tanter, Mickael |
| Ecole Doctorale: | ED 404 PHYSIQUE MACROSCOPIQUE |
| Discipline: | Physique |
| Collection (Fonds): | ESPCI |
| Institution: | ESPCI |
| Department: | Laboratoire Ondes et Acoustique |
| Subjects: | 3. Physics, Optics |
| Uncontrolled Keywords: | Hifu, Focused ultrasound, Brain therapy, Skull, Ultrasound imaging |
Table of content
I Nouvelles techniques d'imagerie pour la therapie ultrasonore
II Correction des mouvements
III Therapie ultrasonore du cerveau
| ID Code: | 992 |
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| Deposited By: | Mathieu Pernot |
| Deposited On: | 10 March 2005 |
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