Georgy, Marie (2006) Towards the total synthesis of Macrolactin A. New gold(III)-catalyzed substitutions of propargylic alcohols. PhD thesis ICSN, ICSN Institut de Chimie des Substances Naturelles, EP/X p.258.
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Alternative Locations: http://www.imprimerie.polytechnique.fr/Theses/Files/Georgy.pdf
Abstract
The first part of this thesis describes a synthetical approach of antimicrobial agent Macrolactin A. This approaoch is based on two original stratégies to build the conjugated systems: one is the isomerisation of a propagylic ketone and the other is a two reaction sequence, namely a Johnson-Claisen reaction followed by an alumina- promoted isomerisation. The stereogenic centres were built by catalytic asymmetric reactions.
The second part of the manuscript describes a new nucleophilic substitution of propargylic alcohols catalyzed by a gold(III) complex.
| Item Type: | PhD Thesis (PhD) |
|---|---|
| Thesis Supervisor: | Campagne, Jean-Marc |
| Date: | November 2006 |
| Board of examiners: | Joëlle, Prunet and Françoise, Colobert and Jean, Rodriguez and Hervé, Bouchard and Jean-Marc, Campagne |
| Ecole Doctorale: | ED 447 ECOLE DOCTORALE DE L'ECOLE POLYTECHNIQUE |
| Discipline: | ICSN |
| Collection (Fonds): | EP/X |
| Institution: | EP/X |
| Department: | ICSN Institut de Chimie des Substances Naturelles |
| Subjects: | 6. Chemistry, Physical Chemistry and Chemical Engineering |
| Uncontrolled Keywords: | Macrolactine, Antimicrobial, Asymmetric synthesis, Johnson-Claisen, Calatysis, Gold, Macrolactine, Antibiotique, Synthèse asymétrique, Johnson-Claisen, Catalyse, Or |
| ID Code: | 2171 |
|---|---|
| Deposited By: | Laurence Vidament |
| Deposited On: | 14 February 2007 |
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